Papilloma - Benign formation of skin tumors and mucous membranes of viral etiology.It has the appearance of the papilla on a narrow base (leg), soft or thick consistency, from light to dark brown.The localization of papillomes on the skin leads to the formation of cosmetic damage, in Larry - impaired breathing, voice, on the mucosa of the internal bodies - ulceration and bleeding.Relapse diseases are possible, the most important complication is malignant degeneration.The removal of paper can be performed by electrical agulations, cryoderuktion, surgical excision, by radio wave method or laser exposure.
General information
Papillomas - This is a disease that affects epithelial cells and skin.The cause of papolate is a human papillomavirus belonging to the Papoviridae family, a papillomavirus group.Among the HPV, high and low oncogenic risk viruses differ.Oncogenicity Papillomi explains the ability of the virus to integrate its DNA in the human cell gen.
Mechanism of infection with the virus of the human papillo
Once in the human body, in the initial phase of the HPV affects the basal cell epithelial cells.Microtrows, Luduffs, Craka and other damage to the skin contribute to the penetration of the papillom virus into the body.Long time a virus can be multiplied primarily, they do not manifest clinically (chronic transport).If the virus spreads in surface layers of the skin, then over time, even with chronic transport of papillom virus, cell hyperplasia was observed.
Since the virus of the human papillom is nested in an external environment, the infection occurs with direct contacts.Forced sexual connections lead to infection;Smoking, pregnancy, endometriosis, lack of vitamins, immunodeficiency predispositions to factors so that the infection occurs when interacting with the virus.The risk of infection increases with frequent contacts with bare human skin, for example, with a massage.
Clinical manifestations of papillom
Papilloma is neoplasm skin or mucosa and looks like a papillary growth that protrudes above the surrounding tissue.Papillomi are localized on the skin, mucosa, in the Inginal region and on the genitals, in some cases are papillomes in the renal pelvis and on the mucous membranes.
Because papillomes consist of connective tissue covered with skin and contains blood vessels, bleeding is possible during trauma.Neoplism grows upward in the form of scattered papers in various directions and looks like a cauliflower.
Skin leather cannot be changed, but in most cases, papillomes have a white to a white to dirty brown.Favorite localization - brush and hand skin.In patients with papillomatosis immunodeficiency is widespread.Primary changes in the skin are beginning to appear 1-6 months after infection.The concentration of viruses in affected areas reaches maximum by 6. months from the moment of infection, that is the period that is most developed.
Depending on the type of virus, the clinical manifestation of papillomes are changeable.So, vulgar papillomes look in the form of solid shocks 1 mm diameter with a rough keratine surface.Vulgar papillomes are prone to merging, and thus often affect significant leather areas.Simple (vulgar) papillomas are localized everywhere, but more often they affect the skin of the fingers and the back of the palms.In children, young people are especially affected by papillomi, it is due to physiological characteristics, because children crawl without clothing.Typically, vulgar papillomas are in groups, but the extended existence of an individual element is possible for several years.The conditions of immunodeficiency and general diseases contribute to the expandment of the process, in isolated cases, vulgar papilloma is malignant.
Cancel papillom agents are PAPC 1.2.4.A few months after the infection on the skin of the sole shows a small shiny that has all the signs of ordinary papillom and is surrounded by protruding hoops.In some cases, small size branches appear around one papillom, which looks like bubbles outwardly.Then a mosaic papillomatosis is diagnosed.
The papillomi on the soles are often painful, especially when walking.In approximately 30% of cases, they are self-conscious, are more often self-assembled on the children's shirt.They are often confused by corns that appear between the fingers with extended compression.However, corn, unlike papillomes, have a smooth surface and retain the skin sample.
Causal flat papillom agents are HPV 3.10.These papillomes unchanged skin color and look in the form of smooth flat cones, sometimes there can be a yellowish or mild pink shade more frequent rounded outlines.Multilppiced papillomes were also found.Neops causes pain, itching, the affected area is Hyperemic.
The film papillomi was diagnosed in half of those who turned over the age of 50 on the skin's neoplasms, are also called Acrochords.They are localized on the skin around the eyes, in the groin in an axillary cavity and on the neck.The yellowish small size shade first appears, which further increases and gradually converts into thick elongated elastic formations up to 5-6 mm.If Acrochords are localized in places where trauma is possible, then they become inflamed and injured.Film papillos are not prone to spontaneous disappearances.In patients with diagnosed threaded papillomas are often observed by rectum polyps.
HPV 13, 32 The cause of local epithelial hyperplasia, which characterizes the appearance on the mucous membranes and on the red border of small papillary neoplasms, which rise above the skin and are pausing.
One of the papillomes that are rarely found are the papillomes of Levandovski-Lutza (Warty Epidermodisfelia).Mostly children and adolescents are ill.Sometimes the nipple epidermodisplasia is a family character.It looks clinically like more red brown papillomes on your hands and legs.If the papillos are in leather areas, which are most sensitive to ultraviolet radiation, and then in 30% of cases they are malignant and overpaid in malignant tumors with germination in neighboring tissues.
HPV, which are pathogenic funds, can be low, medium and high risk of oncological degeneration, therefore, when sharply focused fitness, PCR review should always be implemented.The incubation period is from a few weeks to a few months.Since in some cases, changes in the minimum, these papillos remain unnoticed.The main path of transmission is sexual.The risk group includes people with immunodeficiency and often change sexual partners.Outside, they look like pink or pale gray pigmented truly growth in leg.
In most cases, pain, combustion, itching, irritation notes touching and friction with lower laundry, often injured and bleed.They are localized in Eve vagina, on small Labia, less often, spicy condylomas are located in the vagina and the cervix.The men of the urethra is hit in men.Damage zone depends on sexual behavior in this way, in people who exercise anal contacts, pointed condylomas are located in the perineum and perinal zone.In some cases, pointed condylomas are diagnosed on oral mucosa and on the red lip limit, which is again connected to the characteristics of sexual activity.
Larynx juvenile papillomes are rarely recorded, are caused by HPV 6.11;Mostly children are younger than five sick.The infection occurs during childbirth, when a woman in the work has papillomes in the vagina and a child as he passes by the birth canal, he takes a flush breath.The disease is characterized by papillary growth on vocal bundles, which leads to difficulties in air circulation and speech disorders.
Papilloma diagnosis
The diagnosis of papillom performs a dermatologist or venereologist.Due to a large number of types of viruses it has its characteristics.It is possible to a precise diagnosis based on visual inspection only in the classic case of pointed warts, but this does not provide accurate information about the type of virus and its oncogence.Therefore, in the event of a doubt about the papillomatous nature of neoplasms, PCR diagnostics of DNA viruses are resorted.
PCR diagnostics allows not only to confirm the presence of human papillomavirus in the body and determines its species, but also for diagnosticing how many viruses are in the body at the time of the analysis.This has a diagnostic value, because, finding the percentage of virus and its type content, you can specify approximate periods of infection and identify contact persons to examine and prescribe preventive therapy.PCR diagnostics also provides information on whether papillos have a chronic course or are a consequence of the simultaneous reduction in immunity.Thanks to such information, adequate therapy can be prescribed.
If the only way to treat is removing papillom, then parallel with surgery, biopsy is performed for cytological research.Histological examination of tissue papillomes provides more precise results, as the exam is subject to cells, so the exact location of their layers and structural characteristics of tissues.This gives reliable results on the degree of changes in the body and the probability of malicity, as long-term and non-powerful papillomes are more common to cancer from the discovered HPV with a high degree of onkoris.
As a rule, PCR is diagnostic screening in nature and if the analysis confirms the presence of the virus, then an additional study is carried out.
Papillom treatment
The papillom treatment mode in any case is selected individually.If the HPV is detected during the diagnosis, but there is still no clinical manifestations, and then preventive therapy prescribes cytostatics.It is quite effective and allows you to perform "a virus" for several years. Patients who are HPV carriers are recommended periodically implement the PCR exam and use obstacles to contraception, so that the dangers of human papillomavis infection with their partner.
Inozin Pranbex is a remedy for the treatment of papillomes from the group of antivirus agents, which combat the reproduction of the virus.It is one of the most desirable, because there are immunomodulational properties.Indications for use are diagnosed with papillomes with a combination of other viral infections, such as cytomegalovirus infections, measles and mumps.The presence of herpes viruses, chronic viral hepatitis and immunodeficiency also requires inclusion is professional in treatment mode.Since the therapy of the papillom of debt, the Papillo Pranobex must only be under the supervision of the doctor, because laboratory indicators need to be controlled.The use of immunomodulators and vitamin courses are shown to all patients with HPV.
If there are HPV manifestations on the skin and mucosal membranes, depending on localization and symptoms, recourse to papillom, electrocoagulation, or removing the paper laser.It is possible to use another modern method of surgical treatment - removing papillomes with radio waves.If the papilla has signs of malignancy, then the statement is carried out with the scalpel of the affected area with grasping healthy tissues.
It should be borne in mind that the removal of papillom does not lead to a full recovery, because today there are no drugs that are detailed on the HPV.Therefore, patients with previously diagnosed papillomes need to be occasionally passed by the exam and implement antivirus therapy courses.
Since HPV is mainly transmitted sexually, the only papillom prevention is a barrier method of contraception.When planning pregnancy, it is necessary to diagnose and, if necessary, the treatment of viruses to reduce the probability of child infection during childbirth and in the first years of life.